Publications
2024
MSB Rathnayake, MA Boos, BL Farrugia, GJVM van Osch, KS Stok, Glycosaminoglycan-Mediated Interactions in Articular, Auricular, Meniscal, and Nasal Cartilage, Tissue Engineering Part B, 2023.
A Longoni, G Major, S Jiang, BL Farrugia, D Kieser, T Woodfield, J Rnjak-Kovacina, KS Lim, 'Pristine gelatin incorporation as a strategy to enhance the biofunctionality of poly(vinyl alcohol)-based hydrogels for tissue engineering applications', Biomaterials Science, 2023,
2023
A Longoni, G Major, S Jiang, BL Farrugia, D Kieser, T Woodfield, J Rnjak-Kovacina, KS Lim, 'Pristine gelatin incorporation as a strategy to enhance the biofunctionality of poly(vinyl alcohol)-based hydrogels for tissue engineering applications', Biomaterials Science, 2023,
BL Farrugia, J Melrose, 'The Glycosaminoglycan Side Chains and Modular Core Proteins of Heparan Sulphate Proteoglycans and the Varied Ways They Provide Tissue Protection by Regulating Physiological Processes and Cellular Behaviour', International Journal of Molecular Sciences, 2023, 24, 14101
ML Maciej-Hulme, J Melrose, BL Farrugia, 'Arthritis and Duchenne muscular dystrophy: the role of chondroitin sulfate and its associated proteoglycans in disease pathology and as a diagnostic marker', American Journal of Physiology Cell Physiology, 2023,1, C142 - 152
2022
AJ Hayes, BL Farrugia, IJ Biose, GJ Bix, J Melrose, 'Perlecan, A Multi-Functional, Cell-Instructive, Matrix-Stabilizing Proteoglycan with Roles in Tissue Development Has Relevance to Connective Tissue Repair and Regeneration', Frontiers in Cell and Developmental Biology, 2022, 10
2021
D. M. Costello, I. Huntington, G. Burke, B. Farrugia, A. J. O’Connor, A. J. Costello, B. C. Thomas, P. Dundee, A. Ghazi and N. Corcoran 'A review of simulation training and new 3D computer-generated synthetic organs for robotic surgery education' Journal of Robotic Surgery, 2021, https://doi.org/10.1007/s11701-021-01302-8
B. Farrugia, A. J. Hayes, J. Melrose 'Use of Chondroitin Sulphate to Aid In Vitro Stem Cell Differentiation. In: Götte M., Forsberg-Nilsson K. (eds) Proteoglycans in Stem Cells. Biology of Extracellular Matrix' 2021 Vol 9. Springer, pp 53-93
K. Chandrasekar, B. L. Farrugia, L. Johnson, D. Marks, D. Irving, Z. Elgundi, K. Lau, H. N. Kim, J. Rnjak-Kovacina, M. M. Bilek, J. M. Whitelock, M. S. Lord ‘Effect of recombinant human perlecan domain V tethering method on protein orientation and blood contacting activity on polyvinyl chloride’ Advanced Healthcare Materials, Published 23 April 2021. 10.1002/adhm.202100388
T. R Dargaville, D. G Harkin, J.-R. Park, A. Cavalcanti, E. CL Bolle, F. Medeiros Savi, B. L Farrugia, B. D. Monnery, Y. Bernhard, J. F. R. Van Guyse, A. Podevyn, R. Hoogenboom ‘Poly(2-allylamidopropyl-2-oxazoline)-Based Hydrogels: From Accelerated Gelation Kinetics to In Vivo Compatibility in a Murine Subdermal Implant Model’ Biomacromolecules, 2021 22, 1590-1599
M SB Rathnayake, B L Farrugia, K Kulakova, C EM Ter Voert, G JVM van Osch, K S Stok ‘Macromolecular Interactions in Cartilage Extracellular Matrix Vary According to the Cartilage Type and Location’ Cartilage, Published 22 March 2021
2020
B. Farrugia, S. Smith, C Shu, J Melrose ‘Spatio-temporal Expression of 3-B-3(-) and 7-D-4 Chondroitin Sulphation, Tissue Remodelling and Attempted Repair in An Ovine Model of Intervertebral Disc Degeneration'. Cartilage. 2020, 11, 234-250
Z Elgundi, M Papanicolaou, G. Major, T. R. Cox, J Melrose, J. M. Whitelock, B. L. Farrugia ‘Cancer Metastasis: the role of the extracellular matrix and the heparan sulfate proteoglycan perlecan. Frontiers in Oncology 2020, 9, 1482
2019
S. Thickett, E. Hamilton, G. Yogeswaran, P. Zetterlund, B. Farrugia, M. Lord ‘Enhanced osteogenic differentiation of human mesenchymal progenitor cells on graphene oxide-PLGA hybrid microparticles’ Journal of Functional Biomaterials 2019, 10, 33
B L Farrugia, S Mizumoto, M S Lord, R L O'Grady, R P Kuchel, S Yamada, J M Whitelock. ‘Hyaluronidase-4 is produced by mast cells and can cleave serglycin chondroitin sulfate chains into lower molecular weight forms’ Journal of Biological Chemistry, 2019 294, 11458-11472.
R. Z. Murray, Z. E. West, A. J. Cowin, B. L. Farrugia ‘Development and use of biomaterials as wound healing therapies’ Burns and Trauma 2019; 7: 2.
2018
B. L. Farrugia, Y. Mi, H. N. Kim, J. M. Whitelock, S. M Baker, W. P Wiesmann, Z. Li, P. Maitz, M. S. Lord ‘Chitosan‐Based Heparan Sulfate Mimetics Promote Epidermal Formation in a Human Organotypic Skin Model’ Advanced Functional Materials 2018 28(36) 1802818
B. L. Farrugia, M. S. Lord, J. M. Whitelock, J. Melrose. ‘Harnessing chondroitin sulphate in composite scaffolds to direct progenitor and stem cell function for tissue repair’ Biomaterials Science. 2018 6(5) 947-957
A. Hayes, K. Sugahara, B. Farrugia, J. M Whitelock, B. Caterson, J Melrose ‘Biodiversity of CS-proteoglycan Sulphation Motifs: Chemical Messenger Recognition Modules with Roles in Information Transfer, Control of Cellular Behaviour, Tissue Morphogenesis’ Biochemical Journal 2018, 475, 587-620
B. L. Farrugia, M. S. Lord, J Melrose, J. M. Whitelock. ‘The role of heparan sulfate in inflammation, and the development of biomimetics as anti-inflammatory strategies’ Journal of Histochemistry and Cytochemistry, 2018, 66, 321-336
2017
G. Brown, K. S. Lim, B. L. Farrugia, G. J. Hooper, T. B. Woodfield. ‘Covalent incorporation of heparin improves chondrogenesis in photocurable gelatin-methacryloyl hydrogels’ Macromolecular Bioscience, 2017, 17, 1700158
M. S. Lord, B. Cheng, B. L. Farrugia, S. McCarthy, J. M. Whitelock ‘Platelet factor 4 binds to vascular proteoglycans and controls both growth factor activities and platelet activation’ Journal of Biological Chemistry, 2017, 292, 48-61 DOI:
M. S. Lord, A. L. Ellis, B. L. Farrugia, J M. Whitelock, C. Li, R. L. O’Grady, A. A. DeCarlo ‘Perlecan and vascular endothelial growth factor encoding DNA-loaded chitosan scaffolds promote epithelisation in vivo’, Journal of Controlled Release, 2017, 250, 48-61
2016
J. J. Roberts, B. L. Farrugia, R. A. Green, J. Rnjak-Kovacina, P. J. Martens ‘In situ forming PVA-heparin hydrogels for mild encapsulation and prolonged release of growth factors’ Journal of Tissue Engineering 2016 7, 2041731416677132
B. L. Farrugia, K. Chandrasekar, L. Johnson, J. M. Whitelock, D. C. Marks, D. O. Irving, M. S. Lord ‘Perspectives on the use of biomaterials to store platelets for transfusion’ Biointerphases 2016, 11, 029701
M. S. Lord, B. L. Farrugia, C. M. Y. Yan, J. A. Vassie, J. M. Whitelock ‘Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts’ Journal of Biomedical Materials Research Part A 2016,104, 1736-1746
D. E. Robinson, S. Al-Bataineh, B. L. Farrugia, A. Michelmore, A. J. Cowin, T. R. Dargaville, R. D. Short, L. E. Smith, J. D. Whittle ‘Plasma Polymer and Biomolecule Modification of 3D Scaffolds for Tissue Engineering’ Plasma Process and Polymers 2016, 13, 678-689
B. L. Farrugia, J. M. Whitelock, R. O'Grady, B. Caterson, and M. S. Lord ‘Mast Cells Produce a Unique Chondroitin Sulfate Epitope’ Journal of Histochemistry & Cytochemistry, 2016, 64, 85-98
J. N. Haigh, Y.-m. Chuang, B. L. Farrugia, R. Hoogenboom, P. D. Dalton, T. R. Dargaville. ‘Hierarchically Structured Macroporous Poly(2-oxazoline) Hydrogels’ Macromolecular Rapid Communications 2016, 37, 93-99
2015
B. L. Farrugia, M. S. Lord, J. Melrose, J. M. Whitelock. ‘Can we produce heparin/heparan sulfate using “Mother-Nature” as the gold standard?’ Molecules 2015 20, 4254
M. S. Lord, B. L. Farrugia, J. Rnjak-Kovacina, J. M. Whitelock. ‘Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix’ Expert Review of Molecular Diagnosis 2015 15, 77-95
2014
M. S. Lord, B. M. Tsoi, B. L. Farrugia, S. R. S. Ting, S. Baker, W. P. Wiesmann, J. M. Whitelock. ‘Synthesis and characterization of water soluble biomimetic chitosans for bone and cartilage tissue regeneration’ Journal of Materials Chemistry B 2014 2, 6517-6526
B. L. Farrugia, A. Simmons, M. Jasieniak, H. J. Griesser, L. A. Poole-Warren. ‘Platelet interactions with polyurethane nanocomposites: the effect of organic modifier terminal functionality’ Materials Technology: Advanced Performance Materials 2014, 29, B114-119
B. L. Farrugia, J. M. Whitelock, M. Jung, B. McGrath, R. O’Grady, S. McCarthy, M. S. Lord. ‘Localisation of mast cells and the expression of proteoglycans in response to material implants’ Biomaterials 2014, 35, 1462-1477
N. Bock, M. A. Woodruff, R. Steck, D. W. Hutmacher, B. L. Farrugia, T. R. Dargaville, ‘Composites for delivery of therapeutics: Combining melt electrospun scaffolds with loaded electrosprayed microparticles’ Macromolecular Bioscience 2014, 14, 202-214
2013
B. L. Farrugia, K. Kempe, U.S. Schubert, R. Hoogenboom, T. R. Dargaville, ‘Poly(2-oxazoline) hydrogels for controlled fibroblast attachment’ Biomacromolecules 2013, 14, 2724–2732
B. L. Farrugia, T. D. Brown, Z. Upton, D. W. Hutmacher, P. D. Dalton, T. R. Dargaville, ‘Dermal fibroblast infiltration of poly(ε-caprolactone) scaffolds fabricated by melt electrospinning in a direct writing mode, Biofabrication 2013, 5 025001
S. Dey Sarkar, B. L. Farrugia, T. R. Dargaville, S. Dhara, ‘Chitosan-collagen scaffolds with nano/microfibrous architecture for skin tissue engineering’, Journal of Biomedical Materials Research Part A 2013, 101, 3482- 3492.
S. Dey Sarkar, B. L. Farrugia, T. R. Dargaville, S. Dhara, ‘Physico-chemical/biological properties of tripolyphosphate cross-linked chitosan based nanofibers’ Materials Science and Engineering: C 2013, 33, 1446-1454
T. R. Dargaville, B. L. Farrugia, J. A. Broadbent, S. Pace, Z. Upton, N. H. Voelcker, ‘Sensors and imaging for wound healing: A review’ Biosensors and Bioelectronics 2013, 41, 30-42.
P. D. Dalton, C. Vaquette, B. L. Farrugia, T. R. Dargaville, T. D. Brown, D. W. Hutmacher, ‘Electrospinning and additive manufacturing: converging technologies’ Biomaterials Science 2013, 1, 171-185
Prior to 2013
T. R. Dargaville, R. Forster, B. L. Farrugia, K. Kempe, L. Voorhaar, U. S. Schubert, R. Hoogenboom, ‘Poly(2-oxazoline) hydrogel monoliths via thiol-ene coupling’ Macromolecular Rapid Communications 2012, 33, 1695-1700.
B. L. Farrugia, D. J. Keddie, G. A. George, E. C. Lynam, M. A. Brook, Z. Upton, T. R. Dargaville, ‘An investigation into the effect of amphiphilic siloxane oligomers on dermal fibroblasts’ Journal of Biomedical Materials Research Part A 2012, 100, 1919-1927.
L. A. Poole-Warren, B. Farrugia, N. Fong, E. Hume, A. Simmons, ‘Controlling cell-material interactions with polymer nanocomposites by use of surface modifying additives’ Applied Surface Science 2008, 255, 519-522.
T. L. U. Nguyen, B. Farrugia, T. P. Davis, C. Barner-Kowollik, M. H. Stenzel, ‘Core-shell microspheres with surface grafted poly(vinyl alcohol) as drug carriers for the treatment of hepatocellular carcinoma’ Journal of Polymer Science, Part A: Polymer Chemistry 2007, 45, 3256-3272